CHO-K1-EP2/Gα15-Stable Cell Line
| Catalog Number | CBCL-0154 |
| Price | Online Inquiry |
| Unit Quantity | 1 x 10^6 cells / 1.0 ml |
Introduction
Recombinant CHO-K1 cells have been developed to stably overexpress human prostaglandin E receptor 2 (PTGER2) on their surface. These cells contain high levels of the G protein Gαs, which is crucial for coupling with the receptor in downstream signaling pathways.
Application
Drug screening and biological assays
Background
PTGER2, or the prostaglandin E receptor 2, is another G-protein coupled receptor for PGE2. Unlike PTGER1, PTGER2 activation by PGE2 leads to increased cyclic AMP (cAMP) production, which has anti-inflammatory and immunosuppressive effects. PTGER2 is involved in regulating immune responses, smooth muscle relaxation, and renal function. It is a potential therapeutic target for inflammatory and autoimmune diseases.
Product Information
| Category | GPCR Cell Lines |
| Cell Line Name | CHO-K1-EP2/Gα15-Stable Cell Line |
| Protein Family | Prostanoid receptor |
| Gene | EP2/PTGER2 |
| NCBI Gene ID | 5732 |
| Species | Hamster |
| Host Cell Line | CHOK1 |
| Cell Type | Chinese hamster ovary cell line |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.