CHO-K1-IP1/Gα15-Stable Cell Line
| Catalog Number | CBCL-0156 |
| Price | Online Inquiry |
| Unit Quantity | 1 x 10^6 cells / 1.0 ml |
Introduction
Recombinant CHO-K1 cells have been created to stably overexpress human prostaglandin I2 receptor (PTGIR) on their surface. These cells contain high levels of the G protein Gαs, which is essential for coupling with the receptor in downstream signaling pathways.
Application
Drug screening and biological assays
Background
PTGIR, or the prostaglandin I2 receptor, is a receptor for prostaglandin I2 (prostacyclin, PGI2). PGI2 is a potent vasodilator and inhibitor of platelet aggregation. Activation of PTGIR by PGI2 leads to increased cAMP production, which relaxes vascular smooth muscle and inhibits platelet activation. PTGIR is a target for drugs used to treat pulmonary arterial hypertension and other cardiovascular diseases.
Product Information
| Category | GPCR Cell Lines |
| Cell Line Name | CHO-K1-IP1/Gα15-Stable Cell Line |
| Protein Family | Prostanoid receptor |
| Gene | IP1/PTGIR |
| Species | Hamster |
| Host Cell Line | CHOK1 |
| Cell Type | Chinese hamster ovary cell line |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.