CHO-K1-mouse ADORA2A-Stable Cell Line

Introduction

Recombinant CHO-K1 cells have been created to stably overexpress Mus musculus adenosine A2A receptor (ADORA2A) on their surface. These cells contain high levels of the G protein Gαs, which is crucial for coupling with the receptor in downstream signaling pathways.

Application

Drug screening and biological assays

Background

The adenosine A2A receptor encoded by ADORA2A is an important regulator of neuronal and immune functions. In the central nervous system, it interacts with dopamine receptors to modulate motor activity and reward - seeking behavior. For example, in the basal ganglia, A2A - D2 receptor heteromers play a crucial role in the control of movement. In immune cells, activation of A2A receptors suppresses the activation and proliferation of T cells and reduces the production of inflammatory mediators, contributing to the maintenance of immune homeostasis.

Product Information