CHO-K1-mouse CTLA4-Stable Cell Line
| Catalog Number |
CBCL-0530 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
The CHO-K1-mouse CTLA4-Stable Cell Line consists of recombinant CHO-K1 cells that stably overexpress Mus musculus cytotoxic T-lymphocyte associated protein 4 (CTLA4) on their surface. The surface expression of mouse CTLA4 is confirmed by FACS analysis.
Application
Drug screening and biological assays
Background
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is a key immune checkpoint receptor expressed on activated T cells. It binds to B7 molecules (CD80/CD86) on antigen-presenting cells with higher affinity than CD28, delivering an inhibitory signal that suppresses T cell activation and prevents autoimmune responses. Mutations in CTLA-4 are associated with autoimmune diseases such as type 1 diabetes and autoimmune lymphoproliferative syndrome.
Product Information
| Category |
Immune Checkpoint Cell Lines |
| Cell Line Name |
CHO-K1-mouse CTLA4-Stable Cell Line |
| Protein Family |
Cytotoxic T-lymphocyte-associated protein 4 family |
| Gene |
CTLA4 |
| Species |
Hamster |
| Host Cell Line |
CHOK1 |
| Cell Type |
Chinese hamster ovary cell line |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
Ham’s F-12K (Kaighn’s), 10% FBS, 8 μg/ml Puromycin |
| Freeze Medium |
95% complete growth medium + 5% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
