CHO-K1-NK2-Stable Cell Line

Introduction

Recombinant CHO-K1 cells have been engineered to stably overexpress the human tachykinin receptor 2 (NK2) on their surface, and they contain high levels of the G proteins Gαq and Gαs, which are involved in coupling with the receptor to facilitate downstream signaling pathways.

Application

Drug screening and biological assays

Background

TACR2, or the tachykinin receptor 2 (also known as the neurokinin 2 receptor), is a G-protein coupled receptor that binds neurokinin A, another member of the tachykinin family of neuropeptides. Activation of TACR2 by neurokinin A leads to smooth muscle contraction, increased vascular permeability, and other cellular responses. It is involved in regulating gastrointestinal motility, respiratory function, and inflammatory responses.

Product Information