CHO-K1-PAR2/Gα15-Stable Cell Line

Introduction

Recombinant CHO-K1 cells have been developed to stably overexpress the human protease-activated receptor 2 (PAR2) on their surface, and they contain high levels of the G protein Gαq, which is involved in coupling with the receptor to facilitate downstream signaling pathways.

Application

Drug screening and biological assays

Background

PAR2, or proteinase-activated receptor 2 (also known as F2RL1), is a G-protein coupled receptor that is activated by proteolytic cleavage of its extracellular domain by serine proteases such as trypsin and thrombin. Activation of PAR2 leads to various cellular responses, including inflammation, pain, and smooth muscle contraction. It is involved in the pathogenesis of inflammatory bowel disease, arthritis, and other inflammatory conditions.

Product Information