CHO-K1-PTAFR-Stable Cell Line

Introduction

Recombinant CHO-K1 cells have been created to stably overexpress human platelet activating factor receptor (PTAFR) on their surface. These cells contain high levels of both G protein Gαq and Gαi, which are crucial for coupling with the receptor in downstream signaling pathways.

Application

Drug screening and biological assays

Background

PTAFR, or the platelet-activating factor receptor, is a G-protein coupled receptor that binds platelet-activating factor (PAF). PAF is a potent phospholipid mediator involved in various inflammatory and immune responses. Activation of PTAFR by PAF leads to platelet aggregation, neutrophil activation, and the release of inflammatory mediators, contributing to the pathogenesis of inflammatory diseases such as asthma and sepsis.

Product Information