CHO-K1-SST3/Gα15-Stable Cell Line

Introduction

Recombinant CHO-K1 cells have been created to stably overexpress the human somatostatin receptor 3 (SST3) on their surface, and they contain high levels of the G protein Gαi, which is involved in coupling with the receptor to facilitate downstream signaling pathways.

Application

Drug screening and biological assays

Background

SSTR3, or the somatostatin receptor 3, is a G-protein coupled receptor that binds somatostatin with intermediate affinity. It is primarily expressed in the brain and pituitary gland, where it regulates neurotransmission and hormone secretion. SSTR3 activation leads to decreased intracellular cAMP levels and inhibition of cell proliferation. It is involved in the pathophysiology of neurological and endocrine disorders.

Product Information