CHO-K1-Tim3-Stable Cell Line
| Catalog Number |
CBCL-0535 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
The CHO-K1-Tim3-Stable Cell Line consists of recombinant CHO-K1 cells that stably overexpress human hepatitis A virus cellular receptor 2 (TIM3) on their surface. The surface expression of TIM3 is confirmed by FACS analysis.
Application
Drug screening and biological assays
Background
TIM-3 (T cell immunoglobulin and mucin domain-3) is an immune checkpoint receptor expressed on exhausted T cells, NK cells, and macrophages. It binds to galectin-9, HMGB1, or CEACAM-1, delivering inhibitory signals that promote T cell apoptosis and immune suppression. TIM-3 is a potential target for reversing T cell exhaustion in cancer and chronic infections.
Product Information
| Category |
Immune Checkpoint Cell Lines |
| Cell Line Name |
CHO-K1-Tim3-Stable Cell Line |
| Protein Family |
T cell immunoglobulin and mucin domain-3 family |
| Gene |
Tim3 |
| Species |
Hamster |
| Host Cell Line |
CHOK1 |
| Cell Type |
Chinese hamster ovary cell line |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
Ham’s F-12K (Kaighn’s), 10% FBS, 8 μg/ml Puromycin |
| Freeze Medium |
95% complete growth medium + 5% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
