CHOK1-cyno-ADAM9-Stable Cell Line

Introduction

The CHOK1-cyno-ADAM9-Stable Cell Line is a stable clone of the CHOK1 cell line that expresses the exogenous cyno ADAM9 gene.

Application

Drug screening and biological assays

Background

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene.

Product Information