EGFR-N771del ins GY Stable Ba/F3 Cell Line

Introduction

Stable Ba/F3 clone expressing exogenous EGFR gene withexon20 N771 deletion and GY insertion.

Application

Drug screening and biological assays

Background

EGFR, the Epidermal growth factor receptor, is a cell-surface receptor tyrosine kinase. EGFR overexpression or overactivity have associated witha number of cancers, including the lung cancer and colon cancer. The identification of EGFR as a driver gene has led to the development of anticancer therapeutics agents. Ba/F3, a murine interleukin-3 dependent pro-B cell line is increasingly popular as a model system for assessing both the potency and downstream signaling of kinase oncogenes, and the ability of small-molecule kinase inhibitors to block kinase activity.

Product Information