ETV6-BTK-C481S-F517L Stable Ba/F3 Cell Line

Introduction

Stable Ba/F3 clone expressing exogenous ETV6-BTK fusion gene with C481S/F517L double mutation.

Application

Drug screening and biological assays

Background

Bruton's tyrosine kinase (abbreviated BTK) is a tyrosine kinase, which plays a key role in B cell development and maturation. Ba/F3, a murine interleukin-3 dependent pro-B cell line is increasingly popular as a model system for assessing both the potency and downstream signaling of kinase oncogenes, and the ability of small-molecule kinase inhibitors to block kinase activity.

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