Background
Platelet-derived growth factor receptor A, abbreviated as PDGFRA or PDGFRa, is a cell-surface receptor tyrosine kinase, and activated by binding of its specific ligand, platelet-derived growth factors (PDGFs), play an important role in cell growth and differentiation. The identification of PDGFRA as a driver gene has led to the development of anticancer therapeutics agents.
Ba/F3, a murine interleukin-3 dependent pro-B cell line is increasingly popular as a model system for assessing both the potency and downstream signaling of kinase oncogenes, and the ability of small-molecule kinase inhibitors to block kinase activity.
