HEK293-EP1-Stable Cell Line

Introduction

Recombinant HEK293 cells have been engineered to stably overexpress human prostaglandin E receptor 1 (PTGER1) on their surface. These cells contain high levels of the G protein Gαq, which is essential for coupling with the receptor in downstream signaling pathways.

Application

Drug screening and biological assays

Background

PTGER1, or the prostaglandin E receptor 1, is a G-protein coupled receptor that binds prostaglandin E2 (PGE2). PGE2 is a key mediator of inflammation, pain, and fever. Activation of PTGER1 by PGE2 leads to various cellular responses, including increased vascular permeability, smooth muscle contraction, and pain sensation. PTGER1 is a target for nonsteroidal anti-inflammatory drugs (NSAIDs) that are used to relieve pain and inflammation.

Product Information