HEK293-GIPR/CRE-Luciferase-Reporter Cell Line
| Catalog Number | CBCL-0218 |
| Price | Online Inquiry |
| Unit Quantity | 2 x 10^6 cells / 1.0 ml |
Introduction
Recombinant HEK293 cells expressing the firefly luciferase gene under the control of the cAMP response element (CRE), with forced expression of human GIPR (Gastric Inhibitory Polypeptide receptor, NM_000164.4). Activation of GIPR in these cells can be monitored by measuring luciferase activity. The functionality of the GIPR/CRE Luciferase Reporter HEK293 Cell Line was validated using agonists gastric inhibitory peptide (GIP) and tirzepatide hydrochloride, which induce luciferase activity in a dose-dependent manner.
Application
Screen and characterize agonists of human GIPR in a cellular context
Background
GIPR (Gastric Inhibitory Polypeptide Receptor) is a G protein-coupled receptor that binds GIP and regulates insulin secretion and glucose homeostasis.
Product Information
| Category | CRE Reporter Cell Lines |
| Cell Line Name | HEK293-GIPR/CRE-Luciferase-Reporter Cell Line |
| Protein Family | G protein-coupled receptor family |
| Gene | GIPR |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.