HEK293-Human 5-HT1A (Luc)-Reporter Cell
| Catalog Number | CBCL-0228 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The Human 5-HT1A (Luc) HEK293 Reporter Cell was engineered to express the CREB signaling response element, the full-length human 5-HT1A receptor (Uniprot: P08908), and mGFP using a viral P2A self-cleaving peptide. Stimulation with a human 5-HT1A agonist can drive CREB-mediated luminescence. Inhibition of activated 5-HT1A signaling by corresponding inhibitors results in decreased luminescence.
Application
Screen for 5-HT1A agonist.
Background
5-HT1A (also known as HTR1A) is a serotonin receptor subtype involved in regulating mood, anxiety, and cognitive functions. It is a target for antidepressant and anxiolytic drugs.
Product Information
| Category | Luciferase Reporter Cell Lines |
| Cell Line Name | HEK293-Human 5-HT1A (Luc)-Reporter Cell |
| Protein Family | 5-Hydroxytryptamine receptor |
| Gene | 5-HT1A/HTR1A |
| NCBI Gene ID | 3350 |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.