HEK293-Human Activin RII (Luc)-Reporter Cell
| Catalog Number | CBCL-0229 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The Human Activin RII (Luc) HEK293 Reporter Cell was designed to express the Smad signaling response element driving luciferase expression. Stimulation with multiple ligands, including activin, myostatin, and GDF-11, can trigger Smad-mediated luminescence. Neutralization of the ligand-receptor interaction by corresponding antibodies results in decreased luminescence.
Application
Screen for neutralizing antibodies blocking the ligand-receptor interaction.
Background
Activin RII is a receptor for activins, which are involved in regulating cell growth, differentiation, and apoptosis. It plays a role in various physiological processes, including reproduction and development.
Product Information
| Category | Luciferase Reporter Cell Lines |
| Cell Line Name | HEK293-Human Activin RII (Luc)-Reporter Cell |
| Protein Family | TGF-beta receptor family |
| Gene | Activin RII |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.