HEK293-Human Activin RII (Luc)-Reporter Cell
| Catalog Number |
CBCL-0229 |
| Price |
Online Inquiry |
| Unit Quantity |
5 x 10^6 cells / 1.0 ml |
Introduction
The Human Activin RII (Luc) HEK293 Reporter Cell was designed to express the Smad signaling response element driving luciferase expression. Stimulation with multiple ligands, including activin, myostatin, and GDF-11, can trigger Smad-mediated luminescence. Neutralization of the ligand-receptor interaction by corresponding antibodies results in decreased luminescence.
Application
Screen for neutralizing antibodies blocking the ligand-receptor interaction.
Background
Activin RII is a receptor for activins, which are involved in regulating cell growth, differentiation, and apoptosis. It plays a role in various physiological processes, including reproduction and development.
Product Information
| Category |
Luciferase Reporter Cell Lines |
| Cell Line Name |
HEK293-Human Activin RII (Luc)-Reporter Cell |
| Protein Family |
TGF-beta receptor family |
| Gene |
Activin RII |
| Species |
Human |
| Host Cell Line |
HEK293 |
| Cell Type |
Human embryonic kidney cells |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Selection Marker |
Puromycin (2 μg/mL) |
| Recommended Medium |
DMEM + 10% FBS |
| Freeze Medium |
Serum-free cell cryopreservation medium |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
