HEK293-Human GCGR-Medium Expression-Stable Cell Line
| Catalog Number |
CBCL-0030 |
| Price |
Online Inquiry |
| Unit Quantity |
5 x 10^6 cells / 1.0 ml |
Introduction
A stable HEK293 cell line expressing medium levels of the human glucagon receptor (GCGR). This cell line is optimized for medium expression of GCGR, providing a balanced model for studying receptor function and signaling pathways.
Application
Useful for cell-based GCGR binding assay
Background
The GCGR gene encodes the glucagon receptor, a G protein-coupled receptor. It is mainly expressed in the liver and pancreas. Glucagon binds to its receptor and activates a signaling cascade that leads to the breakdown of glycogen into glucose (glycogenolysis) and the production of glucose from non-carbohydrate sources (gluconeogenesis), thereby increasing blood glucose levels. Dysregulation of glucagon signaling is associated with metabolic disorders, such as diabetes mellitus.
Product Information
| Category |
GPCR Cell Lines |
| Cell Line Name |
HEK293-Human GCGR-Medium Expression-Stable Cell Line |
| Protein Family |
Glucagon receptor family |
| Gene |
GCGR |
| NCBI Gene ID |
2642 |
| Species |
Human |
| Host Cell Line |
HEK293 |
| Cell Type |
Human embryonic kidney cells |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Selection Marker |
Hygromycin B (20 μg/mL) |
| Recommended Medium |
DMEM + 10% FBS |
| Freeze Medium |
Serum-free cell cryopreservation medium |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
