HEK293-Human GIPR-Low Expression-Stable Cell Line
| Catalog Number |
CBCL-0035 |
| Price |
Online Inquiry |
| Unit Quantity |
5 x 10^6 cells / 1.0 ml |
Introduction
A stable HEK293 cell line expressing low levels of the human glucose-dependent insulinotropic polypeptide receptor (GIPR). This cell line is optimized for low expression of GIPR, allowing for the study of receptor function and signaling pathways under conditions of low receptor density.
Application
Useful for cell-based GIPR binding assay
Background
The GIPR gene encodes the glucose-dependent insulinotropic polypeptide (GIP) receptor, a G protein-coupled receptor. It is expressed in pancreatic beta cells. GIP is secreted by the small intestine in response to food intake and binds to its receptor on beta cells, stimulating insulin secretion in a glucose-dependent manner. GIP also has other metabolic effects, such as promoting fat storage and inhibiting gastric emptying. Dysfunction of the GIP signaling pathway is associated with obesity and type 2 diabetes.
Product Information
| Category |
GPCR Cell Lines |
| Cell Line Name |
HEK293-Human GIPR-Low Expression-Stable Cell Line |
| Protein Family |
Class B G-protein-coupled receptor |
| Gene |
GIPR |
| NCBI Gene ID |
2696 |
| Species |
Human |
| Host Cell Line |
HEK293 |
| Cell Type |
Human embryonic kidney cells |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Selection Marker |
Hygromycin B (20 μg/mL) |
| Recommended Medium |
DMEM + 10% FBS |
| Freeze Medium |
Serum-free cell cryopreservation medium |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
