HEK293-Human GLP-1R-Medium Expression-Stable Cell Line
| Catalog Number | CBCL-0039 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
A stable HEK293 cell line expressing medium levels of the human glucagon-like peptide-1 receptor (GLP-1R). This cell line is optimized for medium expression of GLP-1R, providing a balanced model for studying receptor function and signaling pathways.
Application
Useful for cell-based GLP-1R binding assay
Background
The GLP-1R gene encodes the glucagon-like peptide-1 (GLP-1) receptor, a G protein-coupled receptor. It is expressed in pancreatic beta cells, the brain, and the gastrointestinal tract. GLP-1 is secreted by the intestinal L cells in response to food intake and binds to its receptor on beta cells, stimulating insulin secretion in a glucose-dependent manner. GLP-1 also inhibits glucagon secretion, slows gastric emptying, and promotes satiety. GLP-1 receptor agonists are used as drugs for the treatment of type 2 diabetes and obesity.
Product Information
| Category | GPCR Cell Lines |
| Cell Line Name | HEK293-Human GLP-1R-Medium Expression-Stable Cell Line |
| Protein Family | Class B G-protein-coupled receptor |
| Gene | GLP-1R |
| NCBI Gene ID | 2740 |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |