HEK293-Human GLP-2R (Luc)-Reporter Cell
| Catalog Number | CBCL-0041 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
A recombinant HEK293 cell line expressing the human glucagon-like peptide-2 receptor (GLP-2R) fused with a luciferase reporter gene. This cell line is used to study the activation of the GLP-2R receptor and its downstream signaling pathways through luciferase activity.
Application
Screen for agonists that can bind and activate GLP-2R.
Background
The GLP-2R gene encodes the glucagon-like peptide-2 (GLP-2) receptor, a G protein-coupled receptor. It is mainly expressed in the intestinal epithelium. GLP-2 is secreted by the intestinal L cells and plays a crucial role in maintaining intestinal integrity and function. It stimulates intestinal growth, increases nutrient absorption, and enhances the barrier function of the intestinal epithelium. GLP-2 receptor agonists are being investigated for the treatment of various intestinal disorders.
Product Information
| Category | GPCR Cell Lines |
| Cell Line Name | HEK293-Human GLP-2R (Luc)-Reporter Cell |
| Protein Family | Class B G-protein-coupled receptor |
| Gene | GLP-2R |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |