HEK293-Human HVEM (Luc)-Reporter Cell
| Catalog Number | CBCL-0578 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The HEK293-Human HVEM (Luc)-Reporter Cell is engineered to express both the NF-kB signaling response element and the receptor full-length human HVEM (Uniprot: Q92956-1). When co-cultured with target cells expressing human BTLA, the BTLA/HVEM interaction drives NF-kB-mediated luminescence. Blocking the BTLA/HVEM interaction by either anti-BTLA or anti-HVEM antibodies results in a decrease in luminescence.
Application
Screen for anti-human BTLA antibody or anti-human HVEM antibody blocking BTLA/HVEM interaction.
Background
HVEM (Herpesvirus Entry Mediator, TNFRSF14) is a dual-function receptor expressed on immune cells. It binds to LIGHT (TNFSF14, activating) or BTLA/CD160 (inhibitory), modulating lymphocyte activation and immune tolerance. HVEM is involved in autoimmune diseases and tumor immune evasion.
Product Information
| Category | Immune Checkpoint Cell Lines |
| Cell Line Name | HEK293-Human HVEM (Luc)-Reporter Cell |
| Protein Family | TNF receptor superfamily |
| Gene | HVEM |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |