HEK293-Human IGF-1 R (Luc)-Reporter Cell
| Catalog Number | CBCL-0248 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
This cell line is a HEK293-based reporter cell line engineered to express a signaling response element and the full-length human IGF-1 R (Uniprot: P08069). When stimulated with human IGF-1 protein, the IGF-1/IGF-1 R interaction drives RE-mediated luminescence. Neutralization of the biological effect of human IGF-1 protein by corresponding antibodies results in a decrease in luminescence.
Application
Screen for neutralizing antibodies blocking the stimulation of human IGF-1 protein.
Background
IGF-1 R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase that binds IGF-1 and regulates cell growth, proliferation, and survival.
Product Information
| Category | Luciferase Reporter Cell Lines |
| Cell Line Name | HEK293-Human IGF-1 R (Luc)-Reporter Cell |
| Protein Family | Insulin receptor family |
| Gene | IGF-1 R |
| NCBI Gene ID | 3480 |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.