HEK293-Human IL-17 RA/IL-17 RC (Luc)-Reporter Cell
| Catalog Number |
CBCL-0201 |
| Price |
Online Inquiry |
| Unit Quantity |
5 x 10^6 cells / 1.0 ml |
Introduction
The Human IL-17 RA/IL-17 RC (Luc) HEK293 Reporter Cell has been designed to express the NF-KB signaling response element driving luciferase expression systems. Stimulation with human IL-17A or IL-17F protein activates receptor-mediated signaling, driving NF-魏B-mediated luminescence. Neutralization of the biological effect of human IL-17A or IL-17F protein with corresponding antibodies decreases luminescence.
Application
Screen for neutralizing antibodies blocking the stimulation of human IL-17A or human IL-17F protein.
Background
IL - 17 RA and IL - 17 RC are subunits of the interleukin - 17 receptor complex. They form a functional receptor that binds IL - 17 cytokines, which are involved in the regulation of immune responses, inflammation, and host defense against pathogens, especially in the context of autoimmune and infectious diseases.
Product Information
| Category |
Cytokine Receptor Cell Lines |
| Cell Line Name |
HEK293-Human IL-17 RA/IL-17 RC (Luc)-Reporter Cell |
| Protein Family |
Interleukin receptor family |
| Gene |
IL-17 RA/IL-17 RC |
| NCBI Gene ID |
IL - 17 RA: 55540
IL - 17 RC: 84818 |
| Species |
Human |
| Host Cell Line |
HEK293 |
| Cell Type |
Human embryonic kidney cells |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Selection Marker |
Puromycin (2 μg/mL) + Zeocin (20 μg/mL) |
| Recommended Medium |
DMEM + 10% FBS |
| Freeze Medium |
Serum-free cell cryopreservation medium |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
