HEK293-Human IL-21 R/CD132 (Luc)-Reporter Cell

Introduction

The Human IL-21 R/CD132 (Luc) HEK293 Reporter Cell has been constructed to express the STAT3 signaling response element, as well as the full-length human IL-21 R (Uniprot: Q9HBE5) and CD132 (Uniprot: P31785-1) receptors. Stimulation with human IL-21 protein activates the IL-21/IL-21 R interaction, driving STAT3-mediated luminescence. Blocking IL-21 binding to IL-21 R with either anti-IL-21 or anti-IL-21 R antibodies reduces luminescence.

Application

Screen for anti-human IL-21 or anti-human IL-21 R neutralizing antibody.

Background

IL - 21 R (Interleukin 21 Receptor) is a cell - surface receptor that binds interleukin - 21 (IL - 21). It pairs with the common gamma chain (CD132) to form a functional receptor complex. IL - 21 plays important roles in the regulation of T - cell and B - cell responses, antibody production, and the development of immune memory.

Product Information