HEK293-Human IL-21 R/CD132 (Luc)-Reporter Cell
| Catalog Number | CBCL-0204 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The Human IL-21 R/CD132 (Luc) HEK293 Reporter Cell has been constructed to express the STAT3 signaling response element, as well as the full-length human IL-21 R (Uniprot: Q9HBE5) and CD132 (Uniprot: P31785-1) receptors. Stimulation with human IL-21 protein activates the IL-21/IL-21 R interaction, driving STAT3-mediated luminescence. Blocking IL-21 binding to IL-21 R with either anti-IL-21 or anti-IL-21 R antibodies reduces luminescence.
Application
Screen for anti-human IL-21 or anti-human IL-21 R neutralizing antibody.
Background
IL - 21 R (Interleukin 21 Receptor) is a cell - surface receptor that binds interleukin - 21 (IL - 21). It pairs with the common gamma chain (CD132) to form a functional receptor complex. IL - 21 plays important roles in the regulation of T - cell and B - cell responses, antibody production, and the development of immune memory.
Product Information
| Category | Cytokine Receptor Cell Lines |
| Cell Line Name | HEK293-Human IL-21 R/CD132 (Luc)-Reporter Cell |
| Protein Family | Interleukin receptor family |
| Gene | IL-21 R/CD132 |
| NCBI Gene ID | IL - 21 R: 50615 CD132 (IL - 2 R gamma): 3561 |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |