HEK293-Human IL-23 R/IL-12 R beta 1 (Luc)-Reporter Cell
| Catalog Number | CBCL-0206 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The Human IL-23 R/IL-12 R beta 1 (Luc) HEK293 Reporter Cell has been engineered to express the STAT3 signaling response element, as well as the full-length human IL-23 R (Uniprot: Q5VWK5-1) and IL-12 R beta 1 (Uniprot: P42701-1) receptors. Stimulation with human IL-23 protein activates receptor-mediated signaling, driving STAT3-mediated luminescence. Neutralization of the biological effect of the ligand-receptor interaction with corresponding antibodies reduces luminescence.
Application
Screen for anti-human IL-23 neutralizing antibody.
Background
IL - 23 R and IL - 12 R beta 1 are subunits of the receptor complexes for interleukin - 23 (IL - 23) and interleukin - 12 (IL - 12), respectively. These cytokines are important for the differentiation and function of T helper 1 (Th1) and Th17 cells, and are involved in immune responses against pathogens and autoimmune diseases.
Product Information
| Category | Cytokine Receptor Cell Lines |
| Cell Line Name | HEK293-Human IL-23 R/IL-12 R beta 1 (Luc)-Reporter Cell |
| Protein Family | Interleukin receptor family |
| Gene | IL-23 R/IL-12 R beta 1 |
| NCBI Gene ID | IL - 23 R: 149233 IL - 12 R beta 1: 3593 |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |