HEK293-Human IL-4 R alpha/IL-13 R alpha 1 (Luc)-Reporter Cell
| Catalog Number | CBCL-0208 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The Human IL-4 R alpha/IL-13 R alpha 1 (Luc) HEK293 Reporter Cell, which has endogenous IL-4 R alpha and IL-13 R alpha 1 expression, has been engineered to express the STAT6 signaling response element. Stimulation with human IL-4 or IL-13 protein activates receptor-mediated signaling, driving STAT6-mediated luminescence. Neutralization of the biological effect of human IL-4 or IL-13 protein with corresponding antibodies reduces luminescence.
Application
Screen for neutralizing antibodies blocking the stimulation of human IL-4 or IL-13 protein.
Background
IL - 4 R alpha and IL - 13 R alpha 1 are subunits of receptor complexes that bind interleukin - 4 (IL - 4) and interleukin - 13 (IL - 13), respectively. These cytokines are involved in the regulation of Th2 - type immune responses, allergic reactions, and airway inflammation.
Product Information
| Category | Cytokine Receptor Cell Lines |
| Cell Line Name | HEK293-Human IL-4 R alpha/IL-13 R alpha 1 (Luc)-Reporter Cell |
| Protein Family | Interleukin receptor family |
| Gene | IL-4 R alpha/IL-13 R alpha 1 |
| NCBI Gene ID | IL - 4 R alpha: 3566 IL - 13 R alpha 1: 3597 |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |