HEK293-Human IL-5 R alpha/CD131 (Luc)-Reporter Cell
| Catalog Number | CBCL-0209 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The Human IL-5 R alpha/CD131 (Luc) HEK293 Reporter Cell has been designed to express the STAT5 signaling response element, as well as the full-length human IL-5 R alpha (Uniprot: Q01344-1) and CD131 (Uniprot: P32927-1) receptors. Stimulation with human IL-5 protein activates the IL-5/IL-5 R alpha interaction, driving STAT5-mediated luminescence. Blocking IL-5 binding to IL-5 R alpha with either anti-IL-5 or anti-IL-5 R alpha antibodies reduces luminescence.
Application
Screen for anti-human IL-5 or anti-human IL-5 R alpha neutralizing antibody.
Background
IL - 5 R alpha (Interleukin 5 Receptor Alpha) pairs with the common beta chain (CD131) to form the interleukin - 5 receptor complex. IL - 5 is important for the growth, differentiation, and activation of eosinophils, and is involved in allergic responses and asthma.
Product Information
| Category | Cytokine Receptor Cell Lines |
| Cell Line Name | HEK293-Human IL-5 R alpha/CD131 (Luc)-Reporter Cell |
| Protein Family | Interleukin receptor family |
| Gene | IL-5 R alpha/CD131 |
| NCBI Gene ID | IL - 5 R alpha: 3568 CD131 (Common beta chain): 3562 |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |