HEK293-Human IL-7 R alpha/CD132 (Luc)-Reporter Cell
| Catalog Number | CBCL-0210 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The Human IL-7 R alpha/CD132 (Luc) HEK293 Reporter Cell has been engineered to express the STAT5 signaling response element, as well as the full-length human IL-7 R alpha (Uniprot: P16871-1) and CD132 (Uniprot: P31785-1) receptors. Stimulation with human IL-7 protein activates the IL-7 R alpha/CD132 interaction, driving STAT5-mediated luminescence. Neutralization of the biological effect of human IL-7 protein with corresponding antibodies decreases luminescence.
Application
Screen for neutralizing antibodies blocking the stimulation of human IL-7 protein
Background
IL - 7 R alpha (Interleukin 7 Receptor Alpha) combines with the common gamma chain (CD132) to form the interleukin - 7 receptor complex. IL - 7 is crucial for the development, survival, and proliferation of T cells and B cells, especially during early immune system development.
Product Information
| Category | Cytokine Receptor Cell Lines |
| Cell Line Name | HEK293-Human IL-7 R alpha/CD132 (Luc)-Reporter Cell |
| Protein Family | Interleukin receptor family |
| Gene | IL-7 R alpha/CD132 |
| NCBI Gene ID | IL - 7 R alpha: 9021 CD132 (IL - 2 R gamma): 3561 |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |