HEK293-Human PD-L1, GFP Tag-Stable Cell Line

Introduction

The HEK293-Human PD-L1, GFP Tag-Stable Cell Line is used for binding assays by FACS and cell-based ELISA.

Application

Human PD-L1, GFP Tag-HEK293 cells stably expressing exogenous human PD-L1 (Programmed cell death 1 ligand 1, CD274, B7-H1, PDCD1L1, PDCD1LG1, AA sequence : Leu 19 - Leu 238, Protein Acc.# : Q9NZQ7-1). At the same time, GFP protein as a marker was expressed in HEK239/hPD-L1 cells for screening positive cells by FACS.

Background

PD-L1 (Programmed Death-Ligand 1, CD274) is an immune checkpoint molecule expressed on tumor cells, macrophages, and dendritic cells. It binds to PD-1 on T cells, delivering inhibitory signals that suppress T cell activation and promote immune evasion. PD-L1 overexpression correlates with poor cancer prognosis and resistance to immunotherapy.

Product Information