HEK293-Human TGF-beta R (Luc)-Reporter Cell
| Catalog Number | CBCL-0263 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
This HEK293 reporter cell line expresses the Smad signaling response element driving luciferase expression. When stimulated with TGF-beta (TGF-beta 1/2/3) protein, receptor-mediated signaling drives Smad-mediated luminescence. Neutralization of the biological effect of the ligand-receptor interaction by corresponding antibodies results in decreased luminescence.
Application
Screen for neutralizing antibodies blocking the ligand-receptor interaction.
Background
TGF-beta R (Transforming Growth Factor-beta Receptor) is a family of receptors that bind TGF-beta ligands. They regulate cell growth, differentiation, and apoptosis, playing crucial roles in development, tissue homeostasis, and disease.
Product Information
| Category | Luciferase Reporter Cell Lines |
| Cell Line Name | HEK293-Human TGF-beta R (Luc)-Reporter Cell |
| Protein Family | Transforming growth factor beta receptor family |
| Gene | TGF-beta R |
| NCBI Gene ID | 7046 |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.