HEK293-Human TSLP R (Luc)-Reporter Cell
| Catalog Number |
CBCL-0211 |
| Price |
Online Inquiry |
| Unit Quantity |
5 x 10^6 cells / 1.0 ml |
Introduction
The Human TSLP R (Luc) HEK293 Reporter Cell has been constructed to express the STAT5 signaling response element, as well as the full-length human TSLP R (Uniprot: Q9HC73-1) and IL-7 R alpha (Uniprot: P16871-1) receptors. Stimulation with human TSLP protein activates the TSLP/TSLP R interaction, driving STAT5-mediated luminescence. Blocking TSLP binding to TSLP R with either anti-TSLP or anti-TSLP R antibodies reduces luminescence.
Application
Screen for anti-human TSLP or anti-human TSLP R neutralizing antibody.
Background
TSLP R (Thymic Stromal Lymphopoietin Receptor) is a cell - surface receptor that binds thymic stromal lymphopoietin (TSLP). TSLP is involved in the initiation and maintenance of Th2 - type immune responses, and is associated with allergic diseases such as asthma and atopic dermatitis.
Product Information
| Category |
Cytokine Receptor Cell Lines |
| Cell Line Name |
HEK293-Human TSLP R (Luc)-Reporter Cell |
| Protein Family |
Interleukin receptor family |
| Gene |
TSLP R |
| NCBI Gene ID |
TSLPR: 64806 |
| Species |
Human |
| Host Cell Line |
HEK293 |
| Cell Type |
Human embryonic kidney cells |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Selection Marker |
Zeocin (100 μg/mL) + Puromycin (2 μg/mL) |
| Recommended Medium |
DMEM medium + 10% FBS |
| Freeze Medium |
Serum-free cell cryopreservation medium |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
