HEK293-Human TSLP R (Luc)-Reporter Cell
| Catalog Number | CBCL-0211 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
The Human TSLP R (Luc) HEK293 Reporter Cell has been constructed to express the STAT5 signaling response element, as well as the full-length human TSLP R (Uniprot: Q9HC73-1) and IL-7 R alpha (Uniprot: P16871-1) receptors. Stimulation with human TSLP protein activates the TSLP/TSLP R interaction, driving STAT5-mediated luminescence. Blocking TSLP binding to TSLP R with either anti-TSLP or anti-TSLP R antibodies reduces luminescence.
Application
Screen for anti-human TSLP or anti-human TSLP R neutralizing antibody.
Background
TSLP R (Thymic Stromal Lymphopoietin Receptor) is a cell - surface receptor that binds thymic stromal lymphopoietin (TSLP). TSLP is involved in the initiation and maintenance of Th2 - type immune responses, and is associated with allergic diseases such as asthma and atopic dermatitis.
Product Information
| Category | Cytokine Receptor Cell Lines |
| Cell Line Name | HEK293-Human TSLP R (Luc)-Reporter Cell |
| Protein Family | Interleukin receptor family |
| Gene | TSLP R |
| NCBI Gene ID | TSLPR: 64806 |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |