HEK293-Human VEGF R2 (Luc)-Reporter Cell

Introduction

The Human VEGF R2 (Luc) HEK293 Reporter Cell has been designed to express the NFAT signaling response element and the full-length human VEGF R2 (Uniprot: P35968-1). When stimulated with human VEGF protein, the VEGF/VEGF R2 interaction drives NFAT-mediated luminescence. Inhibition of VEGF binding to VEGF R2 by either anti-VEGF or anti-VEGF R2 antibodies results in a decrease in luminescence.

Application

Screen for anti-human VEGF R2 or anti-human VEGF neutralizing antibody.

Background

Vascular endothelial growth factor receptor 2 (VEGFR2) is a receptor tyrosine kinase that binds vascular endothelial growth factor (VEGF), playing a key role in angiogenesis and vascular permeability.

Product Information