HEK293-IL-12 Responsive STAT4 Luciferase Reporter-Stable Cell Line
| Catalog Number |
CBCL-0727 |
| Price |
Online Inquiry |
| Unit Quantity |
2 x 10^6 cells / 1.0 ml |
Introduction
The HEK293-IL-12 Responsive STAT4 Luciferase Reporter-Stable Cell Line has been engineered to express firefly luciferase under the control of the interferon-γ-activated sequence of the interferon regulatory factor 1 (GAS-IRF1) promoter. It also expresses human STAT4 and the human IL-12 receptor complex. IL-12 activity in this cell line can be monitored by measuring luciferase activity.
Application
Drug screening and biological assays
Background
STAT4 (Signal Transducer and Activator of Transcription 4) is a member of the STAT family of transcription factors. It is activated by cytokines such as interleukin - 12 and plays a crucial role in the differentiation of T helper 1 (Th1) cells, immune responses against intracellular pathogens, and the development of autoimmune diseases.
Product Information
| Category |
Cell Signaling Cell Lines |
| Cell Line Name |
HEK293-IL-12 Responsive STAT4 Luciferase Reporter-Stable Cell Line |
| Protein Family |
Signal transducer and activator of transcription family |
| Gene |
STAT4 |
| NCBI Gene ID |
6775 |
| Species |
Human |
| Host Cell Line |
HEK293 |
| Cell Type |
Human embryonic kidney cells |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
DMEM medium + 10% FBS |
| Freeze Medium |
90% FBS + 10% DMSO |
| Storage Method |
Liquid Nitrogen |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
