HEK293-ISRE (Luc)-Reporter Cell
| Catalog Number |
CBCL-0212 |
| Price |
Online Inquiry |
| Unit Quantity |
5 x 10^6 cells / 1.0 ml |
Introduction
he ISRE (Luc) HEK293 Reporter Cell was designed to express IFN-stimulated response elements (ISRE) that drive luciferase expression. When stimulated with human Type I interferons (IFNs), receptor-mediated signaling can trigger IFN-stimulated gene factor 3 (ISGF3)-mediated luminescence.
Application
Screen for activators or inhibitors of Type I interferons.
Background
ISRE (Interferon - Stimulated Response Element) is a cis - acting DNA element found in the promoter regions of interferon - stimulated genes. It is recognized and bound by transcription factors activated by interferons, leading to the transcriptional activation of these genes and the induction of an antiviral and immune - regulatory response.
Product Information
| Category |
Cytokine Receptor Cell Lines |
| Cell Line Name |
HEK293-ISRE (Luc)-Reporter Cell |
| Protein Family |
Interferon-stimulated response element family |
| Gene |
ISRE |
| Species |
Human |
| Host Cell Line |
HEK293 |
| Cell Type |
Human embryonic kidney cells |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Selection Marker |
Puromycin (2 μg/mL) |
| Recommended Medium |
DMEM + 10% FBS |
| Freeze Medium |
Serum-free cell cryopreservation medium |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
