HEK293-NF-κB (Luc)-Reporter Cell

Introduction

This HEK293 reporter cell line is engineered with the NF-kB response element driving luciferase expression systems. The receptors expressed endogenously or transfected on this reporter cell are activated by corresponding ligands binding, transducing intracellular signals resulting in NF-kB-RE mediated luminescence.

Application

The discovery of activators or inhibitors by the NF-kB signaling bioactivity

Background

NF-kB is a transcription factor that regulates the expression of genes involved in immune responses, inflammation, and cell survival. It is activated by various stimuli, including cytokines and pathogens.

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