HEK293-OATP1B1-Cell line
| Catalog Number |
CBCL-0669 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
A new organic anion transporting polypeptide (OATP), designated human OATP2, was cloned and expressed. OATP plays a crucial role in the uptake of various lipophilic anions into the human liver. HEK293 cells were transfected to express the recombinant OATP2 protein on their lateral membrane.
Application
Drug screening and biological assays
Background
Organic anion transporting polypeptide 1B1 (OATP1B1), also known as SLCO1B1, is a membrane transporter protein that mediates the uptake of various endogenous and exogenous organic anions into hepatocytes. OATP1B1 plays a crucial role in the hepatic clearance of many drugs, including statins, and its function can be affected by genetic polymorphisms, leading to interindividual differences in drug disposition and response.
Product Information
| Category |
SLC Transporter Cell Lines |
| Cell Line Name |
HEK293-OATP1B1-Cell line |
| Protein Family |
Organic anion transporting polypeptide family |
| Gene |
OATP1B1 |
| NCBI Gene ID |
10599 |
| Species |
Human |
| Host Cell Line |
HEK293 |
| Cell Type |
Human embryonic kidney cells |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
DMEM medium + 10% FBS |
| Freeze Medium |
80% DMEM + 10% FBS + 10% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
