HEK293-OATP1B3-Cell line
| Catalog Number |
CBCL-0670 |
| Price |
Online Inquiry |
| Unit Quantity |
1 x 10^6 cells / 1.0 ml |
Introduction
A new organic anion transporting polypeptide (OATP), designated human OATP2, was cloned and expressed. OATP plays a crucial role in the uptake of various lipophilic anions into the human liver. HEK293 cells were transfected to express the recombinant OATP2 protein on their lateral membrane.
Application
Drug screening and biological assays
Background
Organic anion transporting polypeptide 1B3 (OATP1B3), also known as SLCO1B3, is another hepatic uptake transporter that shares overlapping substrate specificity with OATP1B1. It mediates the transport of various organic anions, including bile acids, hormones, and drugs, into hepatocytes. OATP1B3 is also subject to genetic polymorphisms that can influence drug pharmacokinetics and pharmacodynamics.
Product Information
| Category |
SLC Transporter Cell Lines |
| Cell Line Name |
HEK293-OATP1B3-Cell line |
| Protein Family |
Organic anion transporting polypeptide family |
| Gene |
OATP1B3 |
| Species |
Human |
| Host Cell Line |
HEK293 |
| Cell Type |
Human embryonic kidney cells |
| Morphology |
Epithelial |
| Growth Properties |
Adherent |
| Recommended Medium |
DMEM medium + 10% FBS |
| Freeze Medium |
80% DMEM + 10% FBS + 11% DMSO |
| Storage Method |
Frozen in liquid nitrogen. |
| Stability |
Validated for at least 10 passages |
| Mycoplasma |
Negative |
| Sterility Testing |
Negative |
| Shipping |
Shipping in dry ice |
| Biosafety Level |
BSL-1 |
| Caution |
For Research Use Only |
For research use only. Not for any other purpose.
