HEK293-STAT3 (Luc)-Reporter Cell

Introduction

The STAT3 (Luc) HEK293 Reporter Cell was created with the STAT3 response element driving luciferase expression. Receptors on this reporter cell, whether endogenously expressed or transfected, can be activated by corresponding ligands, leading to intracellular signaling and STAT3-RE mediated luminescence.

Application

The discovery of activators or inhibitors by the STAT3 signaling bioactivity.

Background

STAT3 (Signal Transducer and Activator of Transcription 3) is a member of the STAT family of transcription factors. It is activated by various cytokines and growth factors and plays important roles in cell proliferation, differentiation, survival, and immune responses. Dysregulation of STAT3 is associated with cancer, autoimmune diseases, and inflammatory disorders.

Product Information