HEK293-TCF/LEF (Luc)-Reporter Cell
| Catalog Number | CBCL-0262 |
| Price | Online Inquiry |
| Unit Quantity | 5 x 10^6 cells / 1.0 ml |
Introduction
This HEK293 reporter cell line expresses the TCF/LEF signaling response element driving luciferase expression, designed to monitor the activity of the Wnt/β-catenin signaling pathway. When stimulated with human Wnt protein, receptor-mediated signaling drives TCF/LEF-mediated luminescence. Inhibition of the biological effect of human Wnt protein by corresponding inhibitors results in decreased luminescence.
Application
Monitor Wnt signaling pathway activity.
Background
TCF/LEF (T-cell factor/lymphoid enhancer-binding factor) is a family of transcription factors that regulate gene expression in response to Wnt signaling, playing a role in development and cancer.
Product Information
| Category | Luciferase Reporter Cell Lines |
| Cell Line Name | HEK293-TCF/LEF (Luc)-Reporter Cell |
| Protein Family | T-cell factor/lymphoid enhancer factor family |
| Gene | TCF/LEF |
| NCBI Gene ID | TCF7/6932 |
| Species | Human |
| Host Cell Line | HEK293 |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |
For research use only. Not for any other purpose.