HEK293-TP-Stable Cell Line

Catalog Number	CBCL-0157
Price	Online Inquiry
Unit Quantity	1 x 10^6 cells / 1.0 ml

Introduction

The HEK293-TP-Stable Cell Line is engineered to stably express the TP (thromboxane A2 receptor).

Application

Drug screening and biological assays

Background

TBXA2R, or the thromboxane A2 receptor, is a G-protein coupled receptor that binds thromboxane A2 (TXA2). TXA2 is a potent vasoconstrictor and platelet aggregator. Activation of TBXA2R by TXA2 leads to platelet aggregation, vasoconstriction, and bronchoconstriction, contributing to the pathogenesis of thrombosis, hypertension, and asthma. TBXA2R antagonists are used to treat these conditions.

Product Information

Category	GPCR Cell Lines
Cell Line Name	HEK293-TP-Stable Cell Line
Protein Family	Prostanoid receptor
Gene	TP/TBXA2R
NCBI Gene ID	6915
Species	Human
Host Cell Line	HEK293
Cell Type	Human embryonic kidney cells
Morphology	Epithelial
Growth Properties	Adherent
Recommended Medium	DMEM, 10% FBS, 300 μg/ml G418
Freeze Medium	45% culture medium + 45% FBS + 10% DMSO
Storage Method	Frozen in liquid nitrogen.
Stability	Validated for at least 10 passages
Mycoplasma	Negative
Sterility Testing	Negative
Shipping	Shipping in dry ice
Biosafety Level	BSL-1
Caution	For Research Use Only

For research use only. Not for any other purpose.