HEK293T-SRF-RE-luc2-Stable Cell Line
| Catalog Number | CBCL-0285 |
| Price | Online Inquiry |
| Unit Quantity | 1 x 10^6 cells / 1.0 ml |
Introduction
This stable HEK293T cell line expresses exogenous luciferase under the control of the RhoA signaling pathway, enabling studies of RhoA-dependent gene expression and signaling events.
Application
Drug screening and biological assays
Background
Serum response factor (SRF) is a transcription factor that binds to the serum response element (SRE) in the promoter region of target genes. SRF regulates the expression of many immediate-early genes, such as c-Fos, and is involved in cell cycle regulation, cell growth, and cell differentiation. SRF is widely expressed in various tissues and plays a crucial role in developmental processes, including cardiac muscle cell differentiation and angiogenesis. The term "SRF-RE" likely refers to the SRE or SRF-responsive element, which is a DNA sequence that binds SRF and mediates its transcriptional activity.
Product Information
| Category | Luciferase Reporter Cell Lines |
| Cell Line Name | HEK293T-SRF-RE-luc2-Stable Cell Line |
| Protein Family | Serum response factor-response element family |
| Gene | SRF-RE |
| Species | Human |
| Host Cell Line | 293T |
| Cell Type | Human embryonic kidney cells |
| Morphology | Epithelial |
| Growth Properties | Adherent |
| Storage Method | Frozen in liquid nitrogen. |
| Stability | Validated for at least 10 passages |
| Mycoplasma | Negative |
| Sterility Testing | Negative |
| Shipping | Shipping in dry ice |
| Caution | For Research Use Only |