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Human CCR5/CCR6 Stable 293T Cell Line

Catalog Number CBCL-379
Price Online Inquiry
Unit Quantity 1x106 cells / 1.0 ml

Introduction

HEK293T cell line stable expressing exogenous human CCR5/CCR6 gene

Application

Drug screening and biological assays

Background

C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. CCRS is predominantly expressed on T cells, macrophages, dendritic cells, eosinophils, microglia and a subpopulation of either breast or prostate cancer cells. CCRS inhibitors blocked the migration and metastasis of breast and prostate cancer cells that expressed CCRS, suggesting that CCR5 may function as a new therapeutic target. Chemokine receptor 6 also known as CCR6 or CD196 is a CCchemokine receptor protein whichin humans is encoded by the CCR6 gene. CCR6 belongs to family A of G protein-coupled receptor superfamily. This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses.

Product Information

Category Immune Molecules Cell Lines
Cell Line Name Human CCR5/CCR6 Stable 293T Cell Line
Pharmaceutical Target Immune Molecules
Species Human
Host Cell Line 293T
Cell Type Human embryonic kidney cells
Morphology Monolayer
Growth Properties Adherent
Selection Marker Puromycin and hygromycin B
Seeding Density Thaw entire contents into an appropriate T25 flask.
Subculture Ratio Recommended a ratio of 1:4-1:5.
Doubling Time Approximately 30 hours
Recommended Medium DMEM + 10% FBS + 0.5 μg/ml Puromycin
Storage Method Frozen in liquid nitrogen with 70% medium, 20% FBS and 10% DMSO
Stability Stable in culture over 10 passages
QC WB
Shipping Shipping in dry ice
Biosafety Level BSL-1
Caution For Research Use Only
For research use only. Not for any other purpose.
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