Background
C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. CCRS is predominantly expressed on T cells, macrophages, dendritic cells, eosinophils, microglia and a subpopulation of either breast or prostate cancer cells. CCRS inhibitors blocked the migration and metastasis of breast and prostate cancer cells that expressed CCRS, suggesting that CCR5 may function as a new therapeutic target. Chemokine receptor 6 also known as CCR6 or CD196 is a CCchemokine receptor protein whichin humans is encoded by the CCR6 gene. CCR6 belongs to family A of G protein-coupled receptor superfamily. This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses.
