Human-ckit Stable Ba/F3 Cell Line

Introduction

Stable Ba/F3 clone expressing exogenous human ckit gene.

Application

Drug screening and biological assays

Background

C-kit also known as CD117, is a type III receptor tyrosine kinase coded by the KIT gene.This gene mutation is associated with gastrointestinal stromal tumors, mast cell disease, acute yelogenous leukemia, and piebaldism. Ba/F3, a murine interleukin-3 dependent pro-B cell line is increasingly popular as a model system for assessing both the potency and downstream signaling of kinase oncogenes, and the ability of small-molecule kinase inhibitors to block kinase activity.

Product Information