Background
Colony Stimulating factor 1 receptor (CSF1R), also named as macrophage colony-stimulating factor receptor (M-CSFR) and CD115, is a single pass type I membrane protein and functions as receptor for the cytokine of colony stimulating factor 1 (CSF 1), the interaction of both molecules controls the production, differentiation and function of macrophages, and is also involved in the development and carcinogenesis of the mammary gland. The identification of CSF1R as drug target has led to repaid development of the inhibitor of CSF1R in the treatment of cancer or inflammatory diseases.
