Human FCGRT-Mutant Stable CHOK1 Cell Line

Introduction

CHOK1 cell line stable expressing exogenous human FCGRT gene bearing L319A & L320A double mutation

Application

Drug screening and biological assays

Background

FCGRT (Fc Fragment of IgG Receptor And Transporter) encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. Diseases associated with FCGRT include Selective Igg Deficiency Disease and Immunodeficiency.

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