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Human LAIR-1 Stable CHOK1 Cell Line

Catalog Number CBCL-585
Price Online Inquiry
Unit Quantity 1x106 cells / 1.0 ml

Introduction

CHOK1 cell line stable expressing exogenous human LAIR-1 gene

Application

Drug screening and biological assays

Background

LAIR-1 (leukocyte associated immunoglobulin like receptor 1, CD305) is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. The binding of LAIR-1 to collagen or C1q results in loss of immune function in the TME and a reduction in T cell function and dendritic cell activity. By blocking the binding of LAIR-1, LAIR-1 inhibitors can promote T cell function and dendritic cell activity, which could result in anti-tumor immune responses that eliminate cancer cells.

Product Information

Category Immune Molecules Cell Lines
Cell Line Name Human LAIR-1 Stable CHOK1 Cell Line
Pharmaceutical Target Immune Molecules
Species Hamster
Host Cell Line CHOK1
Cell Type Chinese hamster ovary cell line
Morphology Monolayer
Growth Properties Adherent
Selection Marker Puromycin
Seeding Density Thaw entire contents into an appropriate T25 flask.
Subculture Ratio Recommended a ratio of 1:4-1:5.
Doubling Time Approximately 24 hours
Recommended Medium F12K + 10% FBS + 6 μg/ml Puromycin
Storage Method Frozen in liquid nitrogen with 70% medium, 20% FBS and 10% DMSO
Stability Stable in culture over 10 passages
QC WB
Shipping Shipping in dry ice
Biosafety Level BSL-1
Caution For Research Use Only
For research use only. Not for any other purpose.
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