Background
LAIR-1 (leukocyte associated immunoglobulin like receptor 1, CD305) is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. The binding of LAIR-1 to collagen or C1q results in loss of immune function in the TME and a reduction in T cell function and dendritic cell activity. By blocking the binding of LAIR-1, LAIR-1 inhibitors can promote T cell function and dendritic cell activity, which could result in anti-tumor immune responses that eliminate cancer cells.
