Background
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K) or ILT3, which is a member of leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 is receptor for class I MHC antigens. LILRB4 involved in the down-regulation of the immune response and the development of tolerance and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
