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Human MDR1 Stable MDCK Cell Line

Catalog Number CBCL-334
Price Online Inquiry
Unit Quantity 1x106 cells / 1.0 ml

Introduction

Stable MDCK cell line expressing exogenous human MDR1 gene

Application

Drug screening and biological assays

Background

MDR1, also known as ABCB1, is a glycoprotein which is a well-characterized ABC-transporter of the MDR/TAP subfamily. MDR1 is an important protein of the cell membrane that pumps many foreign substances out of cells, and itisan ATP-dependent efflux pump with broad substrate specificity. MDR1 is expressed primarily in certain cell types in the liver, pancreas, kidney, colon, and jejunum. MDR1 is also found in brain capillary endothelial cells.

Product Information

Category Immune Molecules Cell Lines
Cell Line Name Human MDR1 Stable MDCK Cell Line
Pharmaceutical Target Immune Molecules
Species Dog
Host Cell Line MDCK
Cell Type Dog canine kidney cells
Morphology Monolayer
Growth Properties Adherent
Selection Marker Puromycin
Seeding Density Thaw entire contents into an appropriate T25 flask.
Subculture Ratio Recommended a ratio of 1:4-1:5.
Recommended Medium DMEM + 10% FBS + 2 μg/ml Puromycin
Storage Method Frozen in liquid nitrogen with 70% medium, 20% FBS and 10% DMSO
Stability Stable in culture over 10 passages
QC WB
Shipping Shipping in dry ice
Biosafety Level BSL-1
Caution For Research Use Only
For research use only. Not for any other purpose.
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