Human SIRPa1 Stable CHOK1 Cell Line

Introduction

CHOK1 cell line stable expressing exogenous human SIRPa1 gene

Application

Drug screening and biological assays

Background

Signal regulatory protein alpha (SIPR alpha), also named CD172a, is a regulatory membrane glycoprotein. SIRPa is expressed mainly on myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells, and also stem cells or neurons. SIRPa acts as inhibitory receptor through recognizing with a broadly expressed transmembrane protein CD47, this interaction also calls “don’t eat me” signal, and negatively regulates phagocytosis of innate immune cells.

Product Information